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Available in capsules. One capsule contains basic substance orlistat 120 mg, and excipients: MCC, sodium starch glycolate, povidone, sodium lauryl atrium; talc. In the blister pack 21 pcs., In a stack of cardboard 1, 2 or 4 blisters.

Long-term therapy of patients with obesity or patients with overweight, including associated with obesity risk factors, in combination with a moderately hypocaloric diet. In combination with antidiabetic drugs (metformin, sulfonylurea drugs and / or insulin) or moderately hypocaloric diet in patients with diabetes mellitus type 2 with overweight or obese

Inside, during, or not later than 1 hour after meals. Adults - 1 capsule. 3 times a day (with every main meal). If the meal is passed or if the food contains no fat, then taking the drug also can be skipped. Increasing the dose of orlistat than recommended (120 mg 3 times a day) does not lead to the strengthening of its therapeutic effect. Dosage adjustment in elderly patients is not required. Correction dose abnormal liver function or kidney is not required. Safety and efficacy of Xenical in children younger than 18 is not installed.

Adverse reactions to orlistat occurred, mainly from the gastrointestinal tract and were due to the pharmacological action of the drug that prevents absorption of fat food. Frequently observed phenomena such as oily discharge from the rectum, the selection of gases with a certain amount of discharge, compelling urge to defecate, steatorrhea, increased frequency of defecation and fecal incontinence.
Their frequency increases with increasing fat content in food. Patients should be informed about the possibility of adverse reactions from the gastrointestinal tract and to teach how to eliminate them through better compliance with the diet, especially as regards the amount of fat contained in it. Application of a diet low in fat reduces the risk of side effects from the gastrointestinal tract and thereby help patients monitor and regulate the consumption of fats. Typically, these side effects are weakly pronounced and transient. They arose in the early stages of treatment (in the first 3 months), with the majority of patients were no more than one episode of such reactions. When treating Ksenikalom often experience the following adverse effects from the gastrointestinal tract: pain or abdominal discomfort, bloating, diarrhea, soft stools, abdominal pain or discomfort in the rectum, the defeat of the teeth, damage to the gums.
There were also infections of the upper or lower respiratory tract, flu, headaches, dysmenorrhea, anxiety, fatigue, urinary tract infections. Described rare cases of allergic reactions, the main clinical symptoms were itching, rash, urticaria, angioedema and anaphylaxis. In patients with diabetes mellitus type 2 in nature and frequency of adverse events were comparable to those in persons without diabetes in overweight and obesity. The only new side effects occurring with a frequency > 2,% and > 1%, compared with placebo, were hypoglycemic state (which could occur as a result of improved compensation of carbohydrate metabolism), and abdominal distension.

No cases of overdose of Xenical has not been described. In clinical studies in patients with normal weight and obese patients receiving single doses of 800 mg or multiple receiving the drug, 400 mg 3 times daily for 15 days was not accompanied by the emergence of significant adverse events. In addition, patients with obesity have experience of orlistat at 240 mg 3 times daily for 6 months, which was not accompanied by a significant increase in the frequency of adverse events.
In pronounced cases of overdose orlistat is recommended to observe the patient within 24 hours according to studies in humans and animals, any systemic effects, which could be attributed to lipazoingibiruyuschimi properties of orlistat should be rapidly reversible.