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Severe forms of acne (nodullyarnaya, defaced acne), purulent spiradenitis, severe forms of rosacea (acne rosacea), congenital ichthyosis, xeroderma pigmentosum. Retinoids are also used to treat severe forms of chronic dermatoses (psoriasis).

Inside, during meals, a daily dose of 0.5 mg / kg for one or more devices. About 4 weeks a transition to the maintenance dose - 0,1-1 mg / kg / day. The maximum daily dose - 1 mg / kg may be administered only for a limited time. Course duration - up to 16 weeks. Treatment can be started only on the second or third day of the normal menstrual cycle. Before re-treatment is followed by a break of at least 8 weeks.

Dryness of mucous membranes, conjunctivitis, photophobia, reduction of twilight vision, cataract, vasculitis, anemia, neutropenia, increase or decrease in platelet count, increased erythrocyte sedimentation rate, hearing loss, local or systemic infections caused by gram-positive microorganisms, in particular, Staphylococcus aureus; skin rash, itching, dermatitis, face, sweating, pyogenic granuloma, paronychia, nail dystrophy, increased proliferation of granulation tissue in the area of acne, hair loss, hirsutism, hyperpigmentation, arthralgia, myalgia, inflammatory bowel disease, hypertriglyceridemia, hyperuricemia, behavioral disorders, depression, headache, increased intracranial pressure, seizures, changes in the bones and hyperostosis (with prolonged use of high doses).

Excess of high doses can cause side effects: dry skin, lips and mucous membranes, infection of the epidermis, cheilitis, skin itching, peeling skin, lihoradochye state, erythema, photosensitivity, nosebleeds, skin dryness and irritation of the eyes, conjunctivitis, eye irritation when wearing contact lenses, hyperlipidemia, increased liver enzymes, headache, hair thinning, myalgia and / or arthralgia.
Also reported the following side effects after prolonged use of isotretinoin: alopecia, arthralgia, worsening of night vision (night blindness), keloid, diseases of the skeletal system.